Nonmyeloablative Allogeneic Stem-Cell Transplantation for Hematologic Malignancies: A Systematic Review
نویسندگان
چکیده
منابع مشابه
Nonmyeloablative allogeneic stem-cell transplantation for hematologic malignancies: a systematic review.
BACKGROUND Increasingly, clinicians advocate the use of nonmyeloablative allogeneic stem-cell transplants (NM-allo-SCTs, "mini-transplants") to manage hematologic malignancies. They hypothesize that NM-allo-SCT is equally efficacious to standard allo-SCT but produces less regimen-related toxicity. METHODS To analyze available evidence on the benefits and harms of "mini-transplants," we identi...
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Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger and fitter patient...
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Histocompatibility in transplantation is governed by the products of the human leucocyte antigen (HLA) genes encoded within the major histocompatibility complex (MHC) on chromosome 6p21. HLA antigens define tissue type and are inherited en bloc in classical Mendelian fashion. Genotypically identical siblings inherit the same paternal and maternal chromosome 6. Haploidentical relatives share one...
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We analyzed the kinetics of donor engraftment among various peripheral blood cell subpopulations and their relationship to outcomes among 120 patients with hematologic malignancies given hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning consisting of 2 Gy total body irradiation (TBI) with or without added fludarabine. While patients rapidly developed high degrees of d...
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We present a case of a patient with metastatic nasopharyngeal carcinoma who failed two lines of palliative combination chemotherapy and was treated with allogeneic nonmyeloablative stem cell transplantation (NST). This patient achieved a durable tumor response, dramatic relief of his symptoms, and elimination of tumor in his bone marrow-an effect likely achieved via a graft-versus-tumor respons...
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ژورنال
عنوان ژورنال: Cancer Control
سال: 2003
ISSN: 1073-2748,1073-2748
DOI: 10.1177/107327480301000104